Product Overview
Blocking/Immunizing peptide for anti-APOC1 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
Function
fatty acid binding; lipase inhibitor activity; phosphatidylcholine binding; phosphatidylcholine-sterol O-acyltransferase activator activity; phospholipase inhibitor activity;
Synonyms
APOC1; apolipoprotein C-I; apo-CIB; apoC-IB; apolipoprotein C1;
Citations
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Meunier, JC; Russell, RS; et al. Apolipoprotein C1 association with hepatitis C virus. JOURNAL OF VIROLOGY 82:9647-9656(2008).
Hueging, K; Doepke, M; et al. Apolipoprotein E Codetermines Tissue Tropism of Hepatitis C Virus and Is Crucial for Viral Cell-to-Cell Transmission by Contributing to a Postenvelopment Step of Assembly. JOURNAL OF VIROLOGY 88:1433-1446(2014).