Rabbit Anti-Human SPESP1 (a.a. 139-344) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse; Rat

Immunogen

Recombinant human SPESP1 protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 139-344 aa of BC017998

Conjugate

Application Notes

WB: 1:500-1:2000

General Notes

This product (Catalog No. CABT-BL265) is a rabbit-derived polyclonal antibody raised against human SPESP1, targeting the amino acid region 139–344 of the protein. This antibody exhibits cross-reactivity with Human SPESP1 from mouse and rat. It has been affinity purified by Protein A. SPESP1 (Sperm Equatorial Segment Protein 1) is a testis-specific protein that is primarily expressed in sperm cells and plays a role in fertilization. It is localized to the equatorial segment of the sperm head, a region that becomes functionally important during sperm–oocyte fusion. SPESP1 is thought to contribute to the structural organization of the sperm membrane and may participate in the binding or fusion processes between sperm and the oocyte plasma membrane. During the acrosome reaction, SPESP1 is redistributed, which is considered important for successful gamete interaction. Expression of SPESP1 is largely restricted to male germ cells, indicating a specialized role in reproductive biology. Although its exact molecular partners and mechanisms are not fully defined, SPESP1 is regarded as a key factor in sperm function and male fertility.
CABT-BL265 is suitable for use in Western blot (WB) (1:500–1:2,000) application.
CABT-BL265 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

Equatorial segment protein; ESP; SP ESP; SPESP1

Entrez Gene ID

UniProt ID