Human AKR1B1 peptide (DAG-P0077)

Specificity
Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.
Nature
Synthetic
Tag/Conjugate
Unconjugated
Sequence Similarities
Belongs to the aldo/keto reductase family.
Cellular Localization
Cytoplasm.
Procedure
None
Purity
70 - 90% by HPLC.
Format
Liquid
Preservative
None
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
UniProt ID
Antigen Description
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]
Function
alditol:NADP+ 1-oxidoreductase activity; aldo-keto reductase (NADP) activity; electron carrier activity; glyceraldehyde oxidoreductase activity;
Synonyms
AKR1B1; aldo-keto reductase family 1, member B1 (aldose reductase); AR; ADR; ALR2; ALDR1; aldose reductase; aldehyde reductase 1; low Km aldose reductase; Lii5-2 CTCL tumor antigen; aldo-keto reductase family 1 member B1;

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References


O'Connor, T; Ireland, LS; et al. Major differences exist in the function and tissue-specific expression of human aflatoxin B-1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. BIOCHEMICAL JOURNAL 343:487-504(1999).
Lefrancois-Martinez, AM; Bertherat, J; et al. Decreased expression of cyclic adenosine monophosphate-regulated aldose reductase (AKR1B1) is associated with malignancy in human sporadic adrenocortical tumors. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 89:3010-3019(2004).

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