Anti-AKR1B1 monoclonal antibody (DMABT-H13014)

Mouse anti-Human AKR1B1 monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
3E23
Species Reactivity
Human
Immunogen
AKR1B1 (AAH00260.1,2a.a. ~ 316 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
AKR1B1; aldo-keto reductase family 1, member B1 (aldose reductase); ALDR1; aldose reductase; AR; aldehyde reductase 1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
AKR1B1 (Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase)) is a Protein Coding gene. Diseases associated with AKR1B1 include diabetic neuropathy and diabetic cataract. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include oxidoreductase activity and aldo-keto reductase (NADP) activity. An important paralog of this gene is AKR1C2. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database.
Antigen Description
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. Aldo-keto reductase family 1, member B1 (aldose reductase), also known as AR, is an enzyme that in humans is encoded by the AKR1B1 gene. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. The function about AKR1B1 antigen include alditol:NADP+ 1-oxidoreductase activity; aldo-keto reductase (NADP) activity; electron carrier activity; glyceraldehyde oxidoreductase activity; oxidoreductase activity.
Pathway
Fructose and mannose metabolism, organism-specific biosystem; Fructose and mannose metabolism, conserved biosystem; Galactose metabolism, organism-specific biosystem; Galactose metabolism, conserved biosystem; Glycerolipid metabolism, organism-specific biosystem; Glycerolipid metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem.

Citations


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References


Lefrancois-Martinez, AM; Bertherat, J; et al. Decreased expression of cyclic adenosine monophosphate-regulated aldose reductase (AKR1B1) is associated with malignancy in human sporadic adrenocortical tumors. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 89:3010-3019(2004).
O'Connor, T; Ireland, LS; et al. Major differences exist in the function and tissue-specific expression of human aflatoxin B-1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. BIOCHEMICAL JOURNAL 343:487-504(1999).

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