Anti-AKAP10 monoclonal antibody (DMABT-H12827)

Mouse anti-Human AKAP10 monoclonal antibody for WB, IHC, sELISA, ELISA, RNAi Knockdown Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
9D20
Species Reactivity
Human, Mouse
Immunogen
AKAP10 (NP_009133,2a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
AKAP10; A kinase (PRKA) anchor protein 10; A-kinase anchor protein 10, mitochondrial; D AKAP2; dual specificity A kinase anchoring protein 2; MGC9414
Entrez Gene ID
UniProt ID

Product Background


Gene summary
AKAP10 (A-Kinase Anchoring Protein 10) is a Protein Coding gene. Diseases associated with AKAP10 include cardiac conduction defect. Among its related pathways are Platelet activation, signaling and aggregation and Factors involved in megakaryocyte development and platelet production. This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death.
Antigen Description
Sudden cardiac death (SCD) [MIM:115080]: Unexpected rapid death due to cardiovascular collapse in a short time period, generally within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e. g. fast basal heart rate and low heart rate variability. A kinase anchor protein 10, mitochondrial is an enzyme that in humans is encoded by the AKAP10 gene. The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein interacts with both the type I and type II regulatory subunits of PKA; therefore, it is a dual-specific AKAP. This protein is highly enriched in mitochondria. It contains RGS (regulator of G protein signalling) domains, in addition to a PKA-RII subunit-binding domain. The mitochondrial localization and the presence of RGS domains may have important implications for the function of this protein in PKA and G protein signal transduction.
Pathway
Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; G Protein Signaling Pathways, organism-specific biosystem; Hemostasis, organism-specific biosystem.

Citations


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References


Hong, GE; Kim, JA; et al. Flavonoids Identified from Korean Scutellaria baicalensis Georgi Inhibit Inflammatory Signaling by Suppressing Activation of NF-kappa B and MAPK in RAW 264.7 Cells. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE :-(2013).

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