Anti-ADPRH monoclonal antibody (DMABT-H12996)

Mouse anti-Human ADPRH monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
2G22
Species Reactivity
Human
Immunogen
ADPRH (NP_001116.1, 23 a.a. ~232a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
ADPRH; ADP-ribosylarginine hydrolase; [Protein ADP-ribosylarginine] hydrolase; ARH1; ADP-ribose-L-arginine cleaving enzyme
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ADPRH (ADP-Ribosylarginine Hydrolase) is a Protein Coding gene. Diseases associated with ADPRH include glycine n-methyltransferase deficiency and mucolipidosis ii alpha/beta. GO annotations related to this gene include magnesium ion binding and ADP-ribosylarginine hydrolase activity. An important paralog of this gene is ADPRHL1. The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described.
Antigen Description
Catalyzes the reverse reaction of mono-ADP-ribosylation. The function about ADPRH antigen include ADP-ribosylarginine hydrolase activity; hydrolase activity; magnesium ion binding.

Citations


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References


MOSS, J; STANLEY, SJ; et al. MOLECULAR AND IMMUNOLOGICAL CHARACTERIZATION OF ADP-RIBOSYLARGININE HYDROLASES. JOURNAL OF BIOLOGICAL CHEMISTRY 267:10481-10488(1992).
TAKADA, T; IIDA, K; et al. CLONING AND SITE-DIRECTED MUTAGENESIS OF HUMAN ADP-RIBOSYLARGININE HYDROLASE. JOURNAL OF BIOLOGICAL CHEMISTRY 268:17837-17843(1993).

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