Product Overview
Blocking/Immunizing peptide for anti-ADAM23 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers.
Function
integrin binding; metalloendopeptidase activity; metallopeptidase activity; protein binding; zinc ion binding;
Synonyms
ADAM23; ADAM metallopeptidase domain 23; a disintegrin and metalloproteinase domain 23; disintegrin and metalloproteinase domain-containing protein 23; MDC3; MDC-3; metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3;
Citations
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Ohkawa, T; Fukata, Y; et al. Autoantibodies to Epilepsy-Related LGI1 in Limbic Encephalitis Neutralize LGI1-ADAM22 Interaction and Reduce Synaptic AMPA Receptors. JOURNAL OF NEUROSCIENCE 33:18161-18174(2013).
Lai, MZ; Huijbers, MGM; et al. Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. LANCET NEUROLOGY 9:776-785(2010).