Product Overview
Blocking/Immunizing peptide for anti-58K Golgi protein(N-Term)/FTCD antibody
Target
58K Golgi protein(N-Term)/FTCD
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009]
Function
folic acid binding; formimidoyltetrahydrofolate cyclodeaminase activity; glutamate formimidoyltransferase activity;
Synonyms
FTCD; formimidoyltransferase cyclodeaminase; LCHC1; formimidoyltransferase-cyclodeaminase; formiminotransferase cyclodeaminase; formiminotransferase-cyclodeaminase;
Citations
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Gao, YS; Alvarez, C; et al. Molecular cloning, characterization, and dynamics of rat formiminotransferase cyclodeaminase, a Golgi-associated 58-kDa protein. JOURNAL OF BIOLOGICAL CHEMISTRY 273:33825-33834(1998).
Lapierre, P; Johanet, C; et al. Characterization of the B cell response of patients with anti-liver cytosol autoantibodies in type 2 autoimmune hepatitis. EUROPEAN JOURNAL OF IMMUNOLOGY 33:1869-1878(2003).