The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene.
Function
protein binding; protein transporter activity;
Synonyms
EIF4ENIF1; eukaryotic translation initiation factor 4E nuclear import factor 1; eukaryotic translation initiation factor 4E transporter; 4E T; 2610509L04Rik; Clast4; FLJ21601; eIF4E transporter; eIF4E-transporter; 4E-T; FLJ26551;
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