17a-OH-Progesterone [HRP] (DAG999)

17a-OH-Progesterone, HRP-conjugated, synthetic

Product Overview
17a-OH-Progesterone, HRP conjugate
Target
Progesterone
Nature
Synthetic
Tag/Conjugate
HRP
Procedure
None
Format
Concentrate
Size
0.5 mL
Preservative
None
Storage
2-8°C short term, -20°C long term
Warnings
PLEASE note that this product is intended for research use only; not for diagnostic or clinical use.
Introduction
Progesterone also known as P4 (pregn-4-ene-3,20-dione) is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. Progesterone belongs to a class of hormones called progestogens, and is the major naturally occurring human progestogen.
Antigen Description
Progesterone is used primarily as a growth promotant in cattle in combinations with estradiol or its esters. When administered exogenously, progesterone enters the same metaboloc pathways and is indistinguishable from the endogenously produced compound.
Keywords
Progesterone; P4; pregn-4-ene-3,20-dione

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References


The Interplay Between Prolactin and Reproductive System: Focus on Uterine Pathophysiology

FRONTIERS IN ENDOCRINOLOGY

Authors: Auriemma, Renata S.; Del Vecchio, Guendalina; Scairati, Roberta; Pirchio, Rosa; Liccardi, Alessia; Verde, Nunzia; de Angelis, Cristina; Menafra, Davide; Pivonello, Claudia; Conforti, Alessandro; Alviggi, Carlo; Pivonello, Rosario; Colao, Annamaria

Over the last years, increasing evidence has focused on crucial pathogenetic role of PRL on malignant, premalignant and benign uterine diseases. Studies in animals and humans have documented that PRL receptors (PRL-Rs) are widely expressed on uterine cells and that PRL is directly synthesized by the endometrium under the stimulatory action of progesterone. Uterine PRL secretion is finely modulated by autocrine/paracrine mechanisms which do not depend on the same control factors implied in the regulation of PRL secretion from pituitary. On the other hand, PRL is synthesized also in the myometrium and directly promotes uterine smooth muscle cell growth and proliferation. Therefore, PRL and PRL-Rs appear to play an important role for the activation of signaling pathways involved in uterine cancers and preneoplastic lesions. Circulating PRL levels are reportedly increased in patients with cervical or endometrial cancers, as well as uterine premalignant lesions, and might be used as discriminative biomarker in patients with uterine cancers. Similarly, increased PRL levels have been implicated in the endometriosis-induced infertility, albeit a clear a causative role for PRL in the pathogenesis of endometriosis is yet to be demonstrated. This evidence has suggested the potential application of dopamine agonists in the therapeutic algorithm of women with malignant, premalignant and benign uterine lesions. This review focuses on the role of PRL as tumorigenic factor for uterus and the outcome of medical treatment with dopamine agonists in patients with malignant and benign uterine disease.

Impairment of Uterine Contractility Is Associated with Unexplained Infertility

SEMINARS IN REPRODUCTIVE MEDICINE

Authors: Hunt, Sarah; Abdallah, Karim S.; Ng, Ernest; Rombauts, Luk; Vollenhoven, Beverley; Mol, Ben W.

The uterine junctional zone represents the juncture between endometrium and myometrium. The junctional zone is hormonally dependent and displays continuous peristaltic activity throughout the menstrual cycle in the nonpregnant state which is concerned with sperm transport and embryo implantation. Peristalsis may be observed using various invasive and noninvasive modalities, of which ultrasound is the most readily applied in the clinical setting. Women with pelvic pathology display alterations in uterine peristalsis which may contribute to infertility. Characterization of peristalsis in infertility subgroups, the development of a subjective peristalsis tool, and the application of potential therapeutics to an assisted reproductive treatment setting are the subject of ongoing investigation. Meta-analysis indicates a potential role for oxytocin antagonist in the improvement of fertility treatments.

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