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New Ebola Antigens

Ebola virus is a member of family Filoviridae, which can cause severe and often fatal hemorrhagic fever in humans and other mammals. Of the four identified strains of Ebola virus, three-the Zaire, Ivory Coast, and Sudan strains-have been shown to cause disease in both humans and nonhuman primates, with the Zaire strain exhibiting the highest lethality rate.

Creative Diagnostics has just released a series of recombinant Ebola antigens including nuclear proteins, glycoproteins and VP40 expressed in E. coli for antibody production and immunoassay purpose.

Our Ebola Viral Antigen Products:

Ebola-Z nuclear protein(aa 630-739)

Ebola-S nuclear protein (aa 629-728)

Ebola-Z glycoprotein (180 aa, mucin like domain)

Ebola-Z VP40 (full length, 380 aa)

1. Alvarez, C. P., F. Lasala, J. Carrillo, A. L. Corbi, and R. Delgado. 2002. C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans. J. Virol. 76:6841-6844.

2. Baize, S., E. M. Leroy, M.-C. Georges-Courbot, M. Capron, J. Lansoud-Soukate, P. Debre, S. P. Fisher-Hoch, J. B. McCormick, and A. J. Georges. 1999. Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients. Nat. Med. 5:423-426.

3. Baskerville, A., E. T. W. Bowen, G. S. Platt, L. B. McArdell, and D. I. H. Simpson. 1978. The pathology of experimental Ebola virus infection in monkeys. J. Pathol. 125:131-138.

4. Baskerville, A., S. P. Fisher-Hoch, G. H. Neild, and A. B. Dowsett. 1985. Ultrastructural pathology of experimental Ebola haemorrhagic fever virus infection. J. Pathol. 147:199-209.

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