Creative Diagnostics is constantly working in order to bring best-in–market reagents for troponin measurements. Now we are offering new reagents for Troponin-I antibody pair for the development of highly sensitive and specific cTnI sandwich immunoassays.
All of the anti-troponin I monoclonal antibodies have been on the clinical diagnostic market since 1998. Among them, clone TPC110 have dominated about 70% of US clinical diagnostic market since 1998. It is still one of the most popular monoclonal antibodies (N24-40 position) for the imunodiagnostic applications of Myocardial Infarction.
Table 1: List of Anti-Troponin I Monoclonal Antibodies
Table 2: Pairing Schemes for Sandwich Enzyme Immunoassays
|Capture||Detection (HRP conjugated)||Min. Sensitivity (ng/ml)|
|DCAB-TJ202 and DCAB-TJ201 (1:1)||DMAB4456MH/DMAB4452MH||0.1|
|DCAB-TJ202 and DCAB-TJ201 and DCAB-TJ203 (1:1:1)||DMAB4456MH/DMAB4452MH||0.1|
*Rated as one of the best pairing for ELISA of troponin I.
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The cardiac marker Troponin I (cTnI) is useful for the diagnosis of myocardial infarction (MI) and the risk stratification to help guide the choice of therapeutic options. The cardiac-specific troponins, Troponin-I (cTnI) and Troponin-T (cTnT) are considered the biochemical markers of choice in the evaluation of acute coronary syndromes (ACS). Elevated levels of cTnI in patients have a statistically significant increase in mortality or increases in other non-fatal cardiac events such as non-fatal MI, congestive heart failure, and urgent revascularization.
Resources:Evaluation of Antibodies to Troponin I