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cTnI Antibody Pairs for Sandwich Immunoassays

Creative Diagnostics is constantly working in order to bring best-in–market reagents for troponin measurements. Now we are offering new reagents for Troponin-I antibody pair for the development of highly sensitive and specific cTnI sandwich immunoassays.

All of the anti-troponin I monoclonal antibodies have been on the clinical diagnostic market since 1998. Among them, clone TPC110 have dominated about 70% of US clinical diagnostic market since 1998. It is still one of the most popular monoclonal antibodies (N24-40 position) for the imunodiagnostic applications of Myocardial Infarction.

Table 1: List of Anti-Troponin I Monoclonal Antibodies

Antibodies Kd Epitope location
DMAB4456MH 0.46nM N 24-40
DMAB4452MH 0.37nM N 24-40
DCAB-TJ202 0.76nM N 24-40
DCAB-TJ201 0.39nM N 59-79
DCAB-TJ203 1.93nM N 80-95

Table 2: Pairing Schemes for Sandwich Enzyme Immunoassays

Capture Detection (HRP conjugated) Min. Sensitivity (ng/ml)
DCAB-TJ202 DMAB4456MH/DMAB4452MH 0.2
DCAB-TJ201 DMAB4456MH/DMAB4452MH 0.1 *
DCAB-TJ203 DMAB4456MH/DMAB4452MH 0.3
DCAB-TJ202 and DCAB-TJ201 (1:1) DMAB4456MH/DMAB4452MH 0.1
DCAB-TJ202 and DCAB-TJ201 and DCAB-TJ203 (1:1:1) DMAB4456MH/DMAB4452MH 0.1

*Rated as one of the best pairing for ELISA of troponin I.

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The cardiac marker Troponin I (cTnI) is useful for the diagnosis of myocardial infarction (MI) and the risk stratification to help guide the choice of therapeutic options. The cardiac-specific troponins, Troponin-I (cTnI) and Troponin-T (cTnT) are considered the biochemical markers of choice in the evaluation of acute coronary syndromes (ACS). Elevated levels of cTnI in patients have a statistically significant increase in mortality or increases in other non-fatal cardiac events such as non-fatal MI, congestive heart failure, and urgent revascularization.

Resources:

Evaluation of Antibodies to Troponin I
ELISA Development Guide
Chemiluminescence Immunoassay Guide
Immunochromatography Guide
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