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Anti-GUCY1B3 monoclonal antibody   (DMAB1506MH)  


Mouse anti-Human GUCY1B3 monoclonal antibody for ELISA, WB           Datasheet

Specifications
Host Species
Mouse
Antibody Isotype
IgG2b
Clone
C246M
Species Reactivity
Human
Immunogen
Recombinant human soluble Guanylate Cyclase alpha 1 beta 1 heterodimer
Conjugate
Unconjugated
Target
Alternative Names
GUCB3; GC-SB3; GUC1B3; GUCSB3; GUCY1B1; GC-S-beta-1; GUCY1B3; GCS-beta-1; GCS-beta-3; guanylate cyclase 1, soluble, beta 3; guanylate cyclase soluble subunit beta-1; Guanylate cyclase soluble subunit beta-3; Soluble guanylate cyclase small subunit
Entrez Gene ID
2983
UniProt ID
Q02153
Product Background
Antigen Description
Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene. Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs. Suitable for use in ELISA and Western blot. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded. The function about GUCY1B3 antigen include GTP binding, guanylate cyclase activity, heme binding, Hsp90 protein binding, ion binding, lyase activity, metal ion binding, nucleotide binding, phosphorus-oxygen lyase activity, protein heterodimerization activity, receptor activity.
Pathway
Formation of Platelet plug; Gap junction; Hemostasis; Long-term depression; Nitric oxide stimulates guanylate cyclase; Platelet Activation; Platelet homeostasis; Purine metabolism; Salivary secretion; Vascular smooth muscle contraction.

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Tel: 1-631-624-4882
Fax: 1-631-938-8221
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Tel: 44-207-048-3343
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