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Anti-DHH monoclonal antibody   (CABT-30792RM)  


Rat anti-Mouse DHH monoclonal antibody for WB           Datasheet

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Specifications
Host Species
Rat
Antibody Isotype
IgG2
Clone
SN0097-7B23
Species Reactivity
Mouse
Immunogen
Mouse recombinant Dhh N-terminal fragment
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/500 - 1/1000.

*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target
Alternative Names
DHH; desert hedgehog; desert hedgehog protein; Desert hedgehog (Drosophila) homolog; Desert hedgehog; Desert hedgehog homolog (Drosophila); Desert hedgehog protein precursor; HHG-3; C78960;
Entrez Gene ID
13363
UniProt ID
Q544P6
Product Background
Gene Summary
DHH (Desert Hedgehog) is a Protein Coding gene. Diseases associated with DHH include 46xy partial gonadal dysgenesis, with minifascicular neuropathy and 46xy sex reversal 7. Among its related pathways are Signaling by GPCR and Infectious disease. GO annotations related to this gene include calcium ion binding and patched binding. An important paralog of this gene is SHH. This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.
Antigen Description
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. 46,XY sex reversal 7 (SRXY7) [MIM:233420]: A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. SRXY7 patients have no functional gonads. Note=The disease may be caused by mutations affecting the gene represented in this entry. Partial gonadal dysgenesis with minifascicular neuropathy 46,XY (PGD) [MIM:607080]: Characterized by the presence of a testis on one side and a streak or an absent gonad at the other, persistence of Muellerian duct structures, and a variable degree of genital ambiguity. Desert hedgehog protein is a protein that in humans is encoded by the DHH gene. Desert hedgehog protein is a member of the Hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. The function about DHH antigen include calcium ion binding; hydrolase activity; peptidase activity; protein binding; zinc ion binding.
Pathway
Hedgehog Signaling Pathway, organism-specific biosystem; Hedgehog signaling pathway, conserved biosystem.
References
Katoh, Y; Katoh, M; et al. Hedgehog signaling pathway and gastric cancer. CANCER BIOLOGY & THERAPY 4:1050-1054(2005).
Sarraj, MA; Escalona, RM; et al. Fetal Testis Dysgenesis and Compromised Leydig Cell Function in Tgfbr3 (Betaglycan) Knockout Mice. BIOLOGY OF REPRODUCTION 82:153-162(2010).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
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