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Anti-SIRT2 monoclonal antibody   (CABT-35791RH)  


Rabbit anti-Human SIRT2 monoclonal antibody for FC, ICC/IF, IP, WB           Datasheet

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Specifications
Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQ2779Z
Species Reactivity
Human
Immunogen
Synthetic peptide corresponding to residues on the C terminus of human SIR2 / SIRT2.
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/1000; IP: 1/50; Flow Cyt: 1/30; ICC/IF: 1/100 - 1/250.

*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target
Alternative Names
SIRT2; sirtuin 2; SIR2L,sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) ,sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; NAD-dependent deacetylase sirtuin-2; NAD dependent deacetylase sirtuin
Entrez Gene ID
22933
UniProt ID
Q8IXJ6
Product Background
Gene Summary
SIRT2 (Sirtuin 2) is a Protein Coding gene. Among its related pathways are p53 Signaling and Signaling events mediated by HDAC Class III. GO annotations related to this gene include chromatin binding and histone deacetylase binding. An important paralog of this gene is SIRT3. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
Pathway
Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class III, organism-specific biosystem.
References
Cen, YN; Falco, JN; et al. Mechanism-based affinity capture of sirtuins. ORGANIC & BIOMOLECULAR CHEMISTRY 9:987-993(2011).
Wang, T; Wang, W; et al. An improved method for rapid preparation of oligodendrocyte-specific rabbit polyclonal antibody. BIOTECHNOLOGY AND BIOPROCESS ENGINEERING 16:470-476(2011).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Tel: 1-631-624-4882
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Tel: 44-207-048-3343
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