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Anti-ROS1 monoclonal antibody   (CABT-34802MH)  


Mouse anti-Human ROS1 monoclonal antibody for FC, ICC/IF, IHC-Fr, IHC-P, IP, WB           Datasheet

Specifications
Host Species
Mouse
Antibody Isotype
IgG1
Clone
5-7H
Species Reactivity
Human
Immunogen
Extracellular portion of ROS amino acid 1-285 fused to Fc, transiently expressed in 293 cells and purified using PtnA column chromatography.
Conjugate
Unconjugated
Target
Alternative Names
ROS1; c-ros oncogene 1 , receptor tyrosine kinase; v ros avian UR2 sarcoma virus oncogene homolog 1 ,v ros UR2 sarcoma virus oncogene homolog 1 (avian); proto-oncogene tyrosine-protein kinase ROS; c ros 1; MCF3; ROS; c ros 1; c ros; c ros1; MCF 3; MCF3; O
Entrez Gene ID
6098
UniProt ID
P08922
Product Background
Gene Summary
ROS1 (ROS Proto-Oncogene 1, Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ROS1 include lung large cell carcinoma and gastric adenocarcinoma. Among its related pathways are ERK Signaling and Akt Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ALK. This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.
Antigen Description
The interleukin 2 receptor is composed of alpha and beta subunits. The beta subunit encoded by this gene is very homologous to the human beta subunit and also shows structural similarity to other cytokine receptors. Note=A chromosomal aberration involving ROS1 is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which is localized to the Golgi and has a constitutive receptor tyrosine kinase activity. A SLC34A2-ROS1 chimeric protein produced in non-small cell lung cancer cells also retains a constitutive kinase activity. A third type of chimeric protein CD74-ROS1 was also identified in those cells. Proto-oncogene tyrosine-protein kinase ROS is an enzyme that in humans is encoded by the ROS1 gene. This proto-oncogene, highly expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. The function about ROS1 antigen include ATP binding; nucleotide binding; protein phosphatase binding; protein tyrosine kinase activity; receptor activity; transmembrane receptor protein tyrosine kinase activity.
References
Go, H; Jung, YJ; et al. Diagnostic method for the detection of KIF5B-RET transformation in lung adenocarcinoma. LUNG CANCER 82:44-50(2013).
Rimkunas, VM; Crosby, KE; et al. Analysis of Receptor Tyrosine Kinase ROS1-Positive Tumors in Non-Small Cell Lung Cancer: Identification of a FIG-ROS1 Fusion. CLINICAL CANCER RESEARCH 18:4449-4457(2012).

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