USA USA / Tel: 1-631-624-4882    Europe Europe / Tel: 44-207-048-3343    Email Email:

Anti-PLA2G10 monoclonal antibody   (CABT-31320RH)  


Rabbit anti-Human PLA2G10 monoclonal antibody for ELISA, WB           Datasheet

  Add to basket
Specifications
Host Species
Rabbit
Antibody Isotype
IgG
Clone
AB47111
Species Reactivity
Human
Immunogen
Recombinant human Phospholipase A2 X. A 15.5 kDa protein containing 123 amino acid residues of the human Phospholipase A2 X and 16 additional amino acid residues, HisTag. Source of immunogen, E.coli
Conjugate
Unconjugated
Applications
Application Notes
WB: 1 μg/ml;

*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target
Alternative Names
PLA2G10; phospholipase A2, group X; group 10 secretory phospholipase A2; GXPLA2; Group X secretory phospholipase A2; GXPLA2; GXSPLA2; Phosphatidylcholine 2 acylhydrolase GX; Phospholipase A2 group X; SPLA2; sPLA2X; sPLA2-X; GX sPLA2; OTTHUMP00000045725; g
Entrez Gene ID
8399
UniProt ID
O15496
Product Background
Gene Summary
PLA2G10 (Phospholipase A2 Group X) is a Protein Coding gene. Diseases associated with PLA2G10 include acute chest syndrome and potters syndrome. Among its related pathways are Metabolism and Fat digestion and absorption. GO annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is PLA2G2C. This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism.
Antigen Description
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine. Group 10 secretory phospholipase A2 is an enzyme that in humans is encoded by the PLA2G10 gene. 0The function about PLA2G10 antigen include calcium ion binding; hydrolase activity; phospholipase A2 activity; phospholipase activity.
Pathway
Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Ether lipid metabolism, organism-specific biosystem; Ether lipid metabolism, conserved biosystem; Fat digestion and absorption, organism-specific biosystem; Fat digestion and absorption, conserved biosystem; Fc epsilon RI signaling pathway, organism-specific biosystem; Fc epsilon RI signaling pathway, conserved biosystem; Glutamatergic synapse, organism-specific biosystem; Glutamatergic sy.
References
HULKOWER, KI; WERTHEIMER, SJ; et al. INTERLEUKIN-1-BETA INDUCES CYTOSOLIC PHOSPHOLIPASE A(2) AND PROSTAGLANDIN-H SYNTHASE IN RHEUMATOID SYNOVIAL FIBROBLASTS - EVIDENCE FOR THEIR ROLES IN THE PRODUCTION OF PROSTAGLANDIN E(2). ARTHRITIS AND RHEUMATISM 37:653-661(1994).
Yokota, Y; et al. Functional analysis of phospholipase A(2) receptor by gene knockout studies. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 121:23-33(2001).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
Learn More

Online Inquiry

Please input "diagnostics" as verification code.
 Online Inquiry
Order Info:Anti-PLA2G10 monoclonal antibody
Interested in larger quantities ? request a quote!
Protocol may be improved. Please feel free to contact us to obtain the latest version.
15% off your first purchase

Contact Us

United States
Tel: 1-631-624-4882
Fax: 1-631-938-8221
Email:

Europe
Tel: 44-207-048-3343
Email:

Ordering Information

Payment methods we support:
✭ Invoice / Purchase Order
✭ Credit card
Credit card

Products
Antibodies
Antigens
Hybridomas
ELISA Kits
Rapid Test Kits
Materials and Reagents
Browse Key Words Alphabetically Hot
United States
Tel: 1-631-624-4882
Fax: 1-631-938-8221
Europe
Tel: 44-207-048-3343
Email

facebook   twitter   linkedin   google+
Distributors 

Home |  Copyright © 2009 - 2017 Creative Diagnostics. All rights reserved.
Inquiry Basket