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Anti-MASP1 monoclonal antibody   (CABT-35271MH)  


Mouse anti-Human MASP1 monoclonal antibody for WB           Datasheet

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Specifications
Host Species
Mouse
Antibody Isotype
IgG2
Clone
NN0208-5G20
Species Reactivity
Human
Immunogen
Recombinant fragment (Human)
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/500 - 1/1000.

*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target
Alternative Names
MASP1; mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor); CRARF,mannan binding lectin serine protease 1 (C4/C2 activating component of Ra reactive factor) , PRSS5; mannan-binding lectin serine protease 1; MASP; Co
Entrez Gene ID
5648
UniProt ID
P48740
Product Background
Gene Summary
MASP1 (Mannan Binding Lectin Serine Peptidase 1) is a Protein Coding gene. Diseases associated with MASP1 include 3mc syndrome 1 and 3mc syndrome. Among its related pathways are Complement and coagulation cascades and Immune System. GO annotations related to this gene include calcium ion binding and serine-type endopeptidase activity. An important paralog of this gene is HP. This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.
Antigen Description
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. MASP-1 is a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. MASP-1 is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. MASP-1 is also able to cleave fibrinogen and factor XIII and may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. The function about MASP1 antigen include calcium ion binding; calcium-dependent protein binding; catalytic activity; peptidase activity; protein binding; protein homodimerization activity; serine-type endopeptidase activity; serine-type endopeptidase activity.
Pathway
Complement Activation, Classical Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Complement cascade, organism-specific biosystem; Creation of C4 and C2 activators, organism-specific biosystem; Immune System, organism-specific biosystem; Initial triggering of complement, organism-specific biosystem; Innate Immune System.
References
Guehrs, KH; Schlott, B; et al. Environmental conditions impinge on dragline silk protein composition. INSECT MOLECULAR BIOLOGY 17:553-564(2008).
Degn, SE; Jensen, L; et al. Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system. JOURNAL OF IMMUNOLOGICAL METHODS 361:37-50(2010).
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