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Anti-FN monoclonal antibody   (DMAB1528MH)  


Mouse anti-Human ITGB5 monoclonal antibody for EIA, WB           Datasheet

Specifications
Host Species
Mouse
Antibody Isotype
IgG1
Clone
C715M
Species Reactivity
Human
Immunogen
Human plasma fibronectin
Conjugate
Unconjugated
Target
Alternative Names
FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2; DKFZp686H0342; DKFZp686I1370; DKFZp686F10164; DKFZp686O13149; FN1; ED-B2; fibronectin OTTHUMP00000164053; OTTHUMP00000164054; OTTHUMP00000164055; OTTHUMP00000164056; OTTHUMP00000206760; OTTHUMP00000206762;
Entrez Gene ID
2335
UniProt ID
P02751
Product Background
Antigen Description
Fibronectin is a high-molecular weight (~440kDa) extracellular matrix glycoprotein that binds to membrane-spanning receptor proteins called integrins. In addition to integrins, fibronectin also binds extracellular matrix components such as collagen, fibrin and heparan sulfate proteoglycans (e. g. syndecans). Fibronectin exists as a dimer, consisting of two nearly identical monomers linked by a pair of disulfide bonds. The fibronectin protein is produced from a single gene, but alternative splicing of its pre-mRNA leads to the creation of several isoforms. The function about FN antigen include Collagen binding; extracellular matrix structural constituent; heparin binding; protein binding.
Pathway
Amoebiasis, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; ECM-receptor interaction, organism-specific biosystem.
References
Hung, WY; Huang, KH; et al. Mitochondrial dysfunction promotes cell migration via reactive oxygen species-enhanced beta 5-integrin expression in human gastric cancer SC-M1 cells. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1820:1102-1110(2012).
Guo, JL; Gu, NL; et al. Neutralization of interleukin-1 beta attenuates silica-induced lung inflammation and fibrosis in C57BL/6 mice. ARCHIVES OF TOXICOLOGY 87:1963-1973(2013).

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