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Anti-CTLA4 monoclonal antibody   (CABT-28212MH)  


Mouse anti-Human CTLA4 monoclonal antibody for FC, ICC, IHC-Fr           Datasheet

Specifications
Host Species
Mouse
Antibody Isotype
IgG2a
Clone
COJ4
Species Reactivity
Human
Immunogen
Human CTLA-4/human IgG heavy chain fusion protein (CTLA-4/Ig).
Conjugate
Unconjugated
Applications
Application Notes
ICC: 5 - 50 μg/ml; Flow Cyt: 2μg/5x 105 cells; IHC-Fr: 5 - 50 μg/ml;

*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target
Alternative Names
CTLA4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte protein 4; CD 152; CD; CD152; CD152 antigen; Celiac disease 3; CELIAC3; CTLA 4; CTLA-4; CTLA4; CTLA4_HUMAN; Cytotoxic T cell associated 4; Cytotoxic T lymphocyte associated 4; Cyto
Entrez Gene ID
1493
UniProt ID
P16410
Product Background
Pathway
Adaptive Immune System, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CTLA4 inhibitory signaling, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune Syst
References
Gassner, FJ; Weiss, L; et al. Fludarabine modulates composition and function of the T cell pool in patients with chronic lymphocytic leukaemia. CANCER IMMUNOLOGY IMMUNOTHERAPY 60:75-85(2011).
Tarhini, AA; Iqbal, F; et al. CTLA-4 blockade: therapeutic potential in cancer treatments. ONCOTARGETS AND THERAPY 3:15-25(2010).

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Tel: 1-631-624-4882
Fax: 1-631-938-8221
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Tel: 44-207-048-3343
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