USA USA / Tel: 1-631-624-4882    Europe Europe / Tel: 44-207-048-3343    Email Email:

Anti-Filamentous HA monoclonal antibody   (DMAB5779)  


Mouse anti-Filamentous HA monoclonal antibody for ELISA, WB, IHC           Datasheet

  Add to basket
Specifications
Host Species
Mouse
Antibody Isotype
IgG1
Clone
IZC 353-02
Species Reactivity
N/A
Immunogen
Whole cell pertussis vaccine + FHA.
Conjugate
Unconjugated
Target
Alternative Names
FHA; Filamentous hemagglutinin
Product Background
Antigen Description
The filamentous h?magglutinin adhesin (FHA) is a large, filamentous protein that serves as a dominant attachment factor for adherence to host colliery epithelia cells of the respiratory tract. It is associated with biofilm formation and possesses at least four binding domains which can bind to different cell receptors on the epithelial cell surface. One notable bacterium that possess filamentous h?magglutinin adhesin is Bordetella pertussis, which uses this protein as a virulence factor. Filamentous hemagglutinin (FHA) of Bordetella pertussis is a 220 kDa large adhesive surface protein which together with the pertussis toxin (PTx) facilitates attachment of the bacteria to human ciliated cells and macrophages during the course of whooping cough. FHA can recognize and bind the leukocyte-restricted adhesion molecule suggesting that FHA mimics a natural ligand on endothelial cells for this integrin which enables FHA to competitively interfere with CD18-dependent leukocyte migration to the central nervous system. Anti FHA antibodies have been shown to be able to permeabilize the blood-brain barrier.
References
Minh, NNT; Edelman, K; et al. Antibody and cell-mediated immune responses to booster immunization with a new acellular pertussis vaccine in school children. VACCINE 16:1604-1610(1998).
van Twillert, I; van Gaans-van den Brink, JAM; et al. Age Related Differences in Dynamics of Specific Memory B Cell Populations after Clinical Pertussis Infection. PLOS ONE 9:-(2014).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
Learn More

Online Inquiry

Please input "diagnostics" as verification code.
 Online Inquiry
Order Info:Anti-Filamentous HA monoclonal antibody
Interested in larger quantities ? request a quote!
Protocol may be improved. Please feel free to contact us to obtain the latest version.
15% off your first purchase

Contact Us

United States
Tel: 1-631-624-4882
Fax: 1-631-938-8221
Email:

Europe
Tel: 44-207-048-3343
Email:

Ordering Information

Payment methods we support:
✭ Invoice / Purchase Order
✭ Credit card
Credit card

Products
Antibodies
Antigens
Hybridomas
ELISA Kits
Rapid Test Kits
Materials and Reagents
Browse Key Words Alphabetically Hot
United States
Tel: 1-631-624-4882
Fax: 1-631-938-8221
Europe
Tel: 44-207-048-3343
Email

facebook   twitter   linkedin   google+
Distributors 

Home |  Copyright © 2009 - 2017 Creative Diagnostics. All rights reserved.
Inquiry Basket