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Anti-EBV Glycoprotein 220 Monoclonal antibody   (DMAB3328)  


Mouse Anti-EBV Glycoprotein 220 Monoclonal antibody for IF, WB           Datasheet

Specifications
Host Species
Mouse
Antibody Isotype
IgG1
Clone
A023
Species Reactivity
EBV
Immunogen
Infected B cell lysate (native protein)
Conjugate
Unconjugated
Target
Alternative Names
BLLF1a; Envelope glycoproteinGp220/340; Envelope glycoprotein GP340/220; Envelope glycoproteinGP340/GP220; Epstein Barr gp350 envelope protein; Epstein Barr virus; EpsteinBarr Virus envelope glycoprotein complex 250/350; Epstein-Barr Virus envelopeglycopr
Product Background
Antigen Description
Epstein-Barr virus is a member of the herpesvirus family and one of the most common human viruses. The envelope glycoprotein Gp340/Gp220 is the most abundant vomponent of the viral envelope and is believed to be responsible for EBV binding to CR2 receptor on human B-Cells. The Epstein–Barrvirus (EBV), also called human herpesvirus 4 (HHV-4), is a virus of theherpes family, which includes herpes simplex virus 1 and 2, and is one of themost common viruses in humans. It is best known as the cause of infectiousmononucleosis. It is also associated with particular forms of cancer,particularly Hodgkin"s lymphoma, Burkitt"s lymphoma, nasopharyngealcarcinoma, and central nervous system lymphomas associated with HIV. Finally,there is evidence that infection with the virus is associated with a higher riskof certain autoimmune diseases, especially dermatomyositis, systemic lupuserythematosus, rheumatoid arthritis, Sjögren"s syndrome, and multiplesclerosis. Suitable for use in IFA and Western blot. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
References
Papworth, MA; VanDijk, AA; et al. The processing, transport and heterologous expression of Epstein-Barr virus gp 110. JOURNAL OF GENERAL VIROLOGY 78:2179-2189(1997).
JILG, W; BOGEDAIN, C; et al. THE EPSTEIN-BARR VIRUS-ENCODED GLYCOPROTEIN GP-110 (BALE-4) CAN SERVE AS A TARGET FOR ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY (ADCC). VIROLOGY 202:974-977(1994).

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Tel: 1-631-624-4882
Fax: 1-631-938-8221
Europe
Tel: 44-207-048-3343
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