USA USA / Tel: 1-631-624-4882    Europe Europe / Tel: 44-207-097-1828    Email Email:

Anti-Aflatoxin monoclonal antibody   (DMAB2947)  


Mouse anti-Aflatoxin monoclonal antibody for IA           Datasheet

  Add to basket
Specifications
Host Species
Mouse
Antibody Isotype
IgG1
Clone
BFA-3
Species Reactivity
N/A
Immunogen
Purified aflatoxin B1
Conjugate
Unconjugated
Target
Alternative Names
AFB1; AFB1-AR1; Aldoketoreductase 7; Aflatoxin
Product Background
Antigen Description
The aflatoxins are agroup of closely related mycotoxins that are widely distributed in nature. The most important of the group is aflatoxin B1 (AFB1), which has a range ofbiological activities, including acute toxicity, teratogenicity, mutagenicityand carcinogenicity. In order for AFB1 to exert its effects, it must beconverted to its reactive epoxide by the action of the mixed functionmono-oxygenase enzyme systems (cytochrome P450-dependent) in the tissues (inparticular, the liver) of the affected animal. This epoxide is highlyreactive and can form derivatives with several cellular macromolecules,including DNA, RNA and protein. Cytochrome P450 enzymes may additionallycatalyse the hydroxylation (to AFQ1 and AFM1) and demethylation (to AFP1) ofthe parent AFB1 molecule, resulting in products less toxic than AFB1. Conjugation of AFB1 to glutathione (mediated by glutathione S-transferase)and its subsequent excretion is regarded as an important detoxificationpathway in animals. Suitable for use at 5ug/ml in immunoassays to identify aflatoxin B1. Dilute in PBS or medium which is identical to that used in the assay system. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
References
Milani, J; Maleki, G; et al. Effects of processing on mycotoxin stability in cereals. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 94:2372-2375(2014).
Peng, X; Zhang, KY; et al. Histological Lesions, Cell Cycle Arrest, Apoptosis and T Cell Subsets Changes of Spleen in Chicken Fed Aflatoxin-contaminated Corn. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 11:8567-8580(2014).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

Online Inquiry

Please input "diagnostics" as verification code.
 Online Inquiry
Order Info:Anti-Aflatoxin monoclonal antibody
Interested in larger quantities ? request a quote!
Protocol may be improved. Please feel free to contact us to obtain the latest version.
15% off your first purchase

Contact Us

United States
Tel: 1-631-624-4882
Fax: 1-631-938-8221
Email:

Europe
Tel: 44-207-097-1828
Email:

Ordering Information

Payment methods we support:
✭ Invoice / Purchase Order
✭ Credit card
Credit card

Products
Antibodies
Antigens
Hybridomas
ELISA Kits
Rapid Test Kits
Materials and Reagents
Browse Key Words Alphabetically Hot
United States
Tel: 1-631-624-4882
Fax: 1-631-938-8221
Europe
Tel: 44-207-097-1828
Email

facebook   twitter   linkedin   google+
Distributors 

Home |  Copyright © 2009 - 2017 Creative Diagnostics. All rights reserved.
Inquiry Basket